S7F (p.Ser7Phe) variant of FOXO3 (Forkhead box protein O3)
S7F (p.Ser7Phe) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
S7F (p.Ser7Phe) variant details
- p.Ser7Phe
- ExAC rs750578104
- gnomAD rs750578104
- Missense
- Variant Prioritization Score for Impact Estimate 0.415
- REVEL 0.24
- MetaLR 0.42
- MetaSVM -0.46
- CADD 22.40
- PolyPhen-2 0.00
- SIFT 0.02
- Most common in the Ashkenazi Jewish population (allele frequency 4e-05)
- Structural context available