A6G (p.Ala6Gly) variant of FOXO3 (Forkhead box protein O3)
A6G (p.Ala6Gly) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
A6G (p.Ala6Gly) variant details
- p.Ala6Gly
- gnomAD 6-108561225-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.365
- REVEL 0.26
- MetaLR 0.39
- MetaSVM -0.49
- CADD 20.70
- PolyPhen-2 0.00
- SIFT 0.30
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- Literature evidence available