E17K (p.Glu17Lys) variant of FOXO3 (Forkhead box protein O3)
E17K (p.Glu17Lys) in FOXO3 (Forkhead box protein O3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
E17K (p.Glu17Lys) variant details
- p.Glu17Lys
- Ensembl rs1775775761
- Missense
- Variant Prioritization Score for Impact Estimate 0.492
- REVEL 0.38
- MetaLR 0.50
- MetaSVM -0.15
- CADD 23.30
- PolyPhen-2 0.01
- SIFT 0.10
- Most common in the East Asian population (allele frequency 5.4e-05)
- Structural context available