TIGIT (Q495A1) variants and mutations

TIGIT (also known as Q495A1) is a human protein-coding gene encoding a t-cell immunoreceptor with Ig and ITIM domains protein. It suppresses T-cell and natural-killer-cell activity after binding ligands such as CD155 and competes with activating receptors for the same ligands. Persistent TIGIT signaling can contribute to immune exhaustion in tumors and chronic infection, making it an immune-checkpoint target. This analysis covers 655 TIGIT variants and mutations. Of these, 79% have computational variant effect predictions. Disease context includes non-small cell lung carcinoma, small cell lung carcinoma, and esophageal squamous cell carcinoma. Example TIGIT variants include M1L, M1V, and M1T.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable TIGIT variants

Examples include M1L, M1V, M1T, M1K, M1R, M1I, R2C, R2G. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.