I33T (p.Ile33Thr) variant of TIGIT (Q495A1)
I33T (p.Ile33Thr) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
I33T (p.Ile33Thr) variant details
- p.Ile33Thr
- gnomAD 3-114295581-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.464
- REVEL 0.39
- MetaLR 0.33
- MetaSVM -0.37
- CADD 23.70
- PolyPhen-2 0.81
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available