L18S (p.Leu18Ser) variant of TIGIT (Q495A1)
L18S (p.Leu18Ser) in TIGIT (Q495A1) is a protein-truncating change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
L18S (p.Leu18Ser) variant details
- p.Leu18Ser
- gnomAD 3-114294109-TC-T
- Frameshift
- Variant Prioritization Score for Impact Estimate 0.164
- CADD 11.80
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- Literature evidence available