W3C (p.Trp3Cys) variant of TIGIT (Q495A1)
W3C (p.Trp3Cys) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data, published literature, and structural context.
W3C (p.Trp3Cys) variant details
- p.Trp3Cys
- gnomAD 3-114294070-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.269
- REVEL 0.07
- MetaLR 0.17
- MetaSVM -0.86
- CADD 23.30
- PolyPhen-2 0.02
- SIFT 0.04
- Most common in the South Asian population (allele frequency 1.3e-05)
- Structural context available
- Literature evidence available