I8T (p.Ile8Thr) variant of TIGIT (Q495A1)
I8T (p.Ile8Thr) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
I8T (p.Ile8Thr) variant details
- p.Ile8Thr
- gnomAD 3-114294084-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.12
- MetaLR 0.11
- MetaSVM -0.95
- CADD 23.20
- PolyPhen-2 0.26
- SIFT 1.00
- Population evidence available
- Structural context available
- Literature evidence available