I27T (p.Ile27Thr) variant of TIGIT (Q495A1)
I27T (p.Ile27Thr) in TIGIT (Q495A1) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
I27T (p.Ile27Thr) variant details
- p.Ile27Thr
- ExAC rs749016800
- gnomAD rs749016800
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.439
- REVEL 0.39
- CADD 22.80
- PolyPhen-2 0.67
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available