L5I (p.Leu5Ile) variant of TIGIT (Q495A1)
L5I (p.Leu5Ile) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data, published literature, and structural context.
L5I (p.Leu5Ile) variant details
- p.Leu5Ile
- gnomAD 3-114294074-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.166
- REVEL 0.05
- MetaLR 0.10
- MetaSVM -1.01
- CADD 16.10
- PolyPhen-2 0.20
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available
- Literature evidence available