I27M (p.Ile27Met) variant of TIGIT (Q495A1)
I27M (p.Ile27Met) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
I27M (p.Ile27Met) variant details
- p.Ile27Met
- ExAC rs768453703
- gnomAD rs768453703
- Missense
- Variant Prioritization Score for Impact Estimate 0.13
- REVEL 0.11
- CADD 13.00
- PolyPhen-2 0.15
- SIFT 0.03
- Most common in the South Asian population (allele frequency 5.8e-05)
- Structural context available