C4G (p.Cys4Gly) variant of TIGIT (Q495A1)
C4G (p.Cys4Gly) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
C4G (p.Cys4Gly) variant details
- p.Cys4Gly
- gnomAD rs1360039945
- Missense
- Variant Prioritization Score for Impact Estimate 0.225
- REVEL 0.15
- CADD 21.60
- PolyPhen-2 0.14
- SIFT 0.10
- Most common in the South Asian population (allele frequency 1.3e-05)
- Structural context available