L43F (p.Leu43Phe) variant of TIGIT (Q495A1)
L43F (p.Leu43Phe) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
L43F (p.Leu43Phe) variant details
- p.Leu43Phe
- gnomAD rs1429798923
- Missense
- Variant Prioritization Score for Impact Estimate 0.435
- REVEL 0.61
- CADD 17.90
- PolyPhen-2 0.67
- SIFT 0.05
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available