S34F (p.Ser34Phe) variant of TIGIT (Q495A1)
S34F (p.Ser34Phe) in TIGIT (Q495A1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
S34F (p.Ser34Phe) variant details
- p.Ser34Phe
- rs1441981882
- NCI-TCGA Cosmic COSV6732
- cosmic curated COSV67329
- TOPMed rs1441981882
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.444
- REVEL 0.37
- CADD 24.00
- PolyPhen-2 0.98
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available