G21E (p.Gly21Glu) variant of TIGIT (Q495A1)
G21E (p.Gly21Glu) in TIGIT (Q495A1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
G21E (p.Gly21Glu) variant details
- p.Gly21Glu
- NCI-TCGA Cosmic COSV6732
- cosmic curated COSV67328
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.198
- REVEL 0.04
- CADD 21.20
- PolyPhen-2 0.20
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available