C4Y (p.Cys4Tyr) variant of TIGIT (Q495A1)
C4Y (p.Cys4Tyr) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
C4Y (p.Cys4Tyr) variant details
- p.Cys4Tyr
- gnomAD rs1425212224
- Missense
- Variant Prioritization Score for Impact Estimate 0.218
- REVEL 0.07
- CADD 12.60
- PolyPhen-2 0.00
- SIFT 0.48
- Most common in the East Asian population (allele frequency 2.8e-05)
- Structural context available