W3S (p.Trp3Ser) variant of TIGIT (Q495A1)
W3S (p.Trp3Ser) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, published literature, and structural context.
W3S (p.Trp3Ser) variant details
- p.Trp3Ser
- gnomAD 3-114294069-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.332
- REVEL 0.26
- MetaLR 0.19
- MetaSVM -0.66
- CADD 25.00
- PolyPhen-2 0.46
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 2.8e-06)
- Structural context available
- Literature evidence available