G12W (p.Gly12Trp) variant of TIGIT (Q495A1)
G12W (p.Gly12Trp) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data, published literature, and structural context.
G12W (p.Gly12Trp) variant details
- p.Gly12Trp
- gnomAD 3-114294095-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.335
- REVEL 0.23
- MetaLR 0.25
- MetaSVM -0.74
- CADD 24.80
- PolyPhen-2 0.98
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available