A35S (p.Ala35Ser) variant of TIGIT (Q495A1)
A35S (p.Ala35Ser) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
A35S (p.Ala35Ser) variant details
- p.Ala35Ser
- gnomAD rs1193996002
- Missense
- Variant Prioritization Score for Impact Estimate 0.565
- REVEL 0.42
- CADD 23.80
- PolyPhen-2 0.97
- SIFT 0.01
- Most common in the South Asian population (allele frequency 4.6e-05)
- Structural context available