S40T (p.Ser40Thr) variant of TIGIT (Q495A1)
S40T (p.Ser40Thr) in TIGIT (Q495A1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
S40T (p.Ser40Thr) variant details
- p.Ser40Thr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.359
- CADD 9.57
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.4e-05)
- Structural context available