R14S (p.Arg14Ser) variant of TIGIT (Q495A1)
R14S (p.Arg14Ser) in TIGIT (Q495A1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
R14S (p.Arg14Ser) variant details
- p.Arg14Ser
- ExAC rs771830740
- gnomAD rs771830740
- Missense
- Variant Prioritization Score for Impact Estimate 0.167
- REVEL 0.08
- CADD 15.30
- PolyPhen-2 0.06
- SIFT 0.07
- Most common in the Latino/Admixed American population (allele frequency 2.8e-05)
- Structural context available