MAPK3 (P27361) variants and mutations

MAPK3 (also known as P27361) is a human protein-coding gene encoding a mitogen-activated protein kinase 3 protein. It works with ERK2 to transmit growth-factor and mitogen signals to transcriptional and cytoplasmic targets. Abnormal ERK activation is a hallmark of many RAS-MAPK-driven cancers and developmental syndromes. This analysis covers 729 MAPK3 variants and mutations. Of these, 75% have computational variant effect predictions. Disease context includes cancer, Noonan syndrome, and hypertrophic cardiomyopathy. Example MAPK3 variants include A2E, A2G, and A2V.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable MAPK3 variants

Examples include A2E, A2G, A2V, A3E, A3G, A3T, A3V, A4E. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.