E88K (p.Glu88Lys) variant of MAPK3 (P27361)
E88K (p.Glu88Lys) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.87 / 1. The record also includes population frequency data and structural context.
E88K (p.Glu88Lys) variant details
- p.Glu88Lys
- rs1315743155
- TOPMed rs1315743155
- gnomAD rs1315743155
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.869
- REVEL 0.94
- CADD 28.50
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available