G11A (p.Gly11Ala) variant of MAPK3 (P27361)
G11A (p.Gly11Ala) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
G11A (p.Gly11Ala) variant details
- p.Gly11Ala
- TOPMed rs955881745
- gnomAD rs955881745
- NCI-TCGA Cosmic COSV5377
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.273
- REVEL 0.14
- CADD 16.30
- PolyPhen-2 0.00
- SIFT 0.68
- UniProt: Variant assessed as somatic; high impact.
- Most common in the REMAINING population (allele frequency 4.1e-05)
- Structural context available