L92V (p.Leu92Val) variant of MAPK3 (P27361)
L92V (p.Leu92Val) in MAPK3 (P27361) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
L92V (p.Leu92Val) variant details
- p.Leu92Val
- gnomAD rs1209777305
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.414
- REVEL 0.54
- CADD 22.90
- PolyPhen-2 0.97
- SIFT 0.01
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available