A2E (p.Ala2Glu) variant of MAPK3 (P27361)
A2E (p.Ala2Glu) in MAPK3 (P27361) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
A2E (p.Ala2Glu) variant details
- p.Ala2Glu
- gnomAD rs1186880470
- Missense
- Variant Prioritization Score for Impact Estimate 0.338
- REVEL 0.29
- CADD 22.40
- PolyPhen-2 0.00
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available