S58* (p.Ser58Ter) variant of MAPK3 (P27361)
S58* (p.Ser58Ter) in MAPK3 (P27361) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes structural context.
S58* (p.Ser58Ter) variant details
- p.Ser58Ter
- rs1370684329
- gnomAD rs1370684329
- Variant assessed as somatic; high impact.
- Stop Gained
- Variant Prioritization Score for Impact Estimate 0.421
- AlphaMissense 0.68
- MetaLR 0.24
- MetaSVM -0.39
- PolyPhen-2 1.00
- SIFT 0.00
- MutPred 0.53
- UniProt: Variant assessed as somatic; high impact.
- Structural context available