L45F (p.Leu45Phe) variant of MAPK3 (P27361)
L45F (p.Leu45Phe) in MAPK3 (P27361) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
L45F (p.Leu45Phe) variant details
- p.Leu45Phe
- ExAC rs751628704
- gnomAD rs751628704
- Missense
- Variant Prioritization Score for Impact Estimate 0.21
- REVEL 0.11
- CADD 19.90
- PolyPhen-2 0.14
- SIFT 0.07
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available