V31G (p.Val31Gly) variant of MAPK3 (P27361)
V31G (p.Val31Gly) in MAPK3 (P27361) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
V31G (p.Val31Gly) variant details
- p.Val31Gly
- ESP rs375146669
- ExAC rs375146669
- TOPMed rs375146669
- gnomAD rs375146669
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.402
- REVEL 0.43
- CADD 23.70
- PolyPhen-2 0.06
- SIFT 0.07
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 5.2e-05)
- Structural context available