T85M (p.Thr85Met) variant of MAPK3 (P27361)
T85M (p.Thr85Met) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
T85M (p.Thr85Met) variant details
- p.Thr85Met
- cosmic curated COSV10960
- NCI-TCGA TCGA novel
- TOPMed rs1375850297
- gnomAD rs1375850297
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.686
- REVEL 0.61
- CADD 29.20
- PolyPhen-2 0.99
- SIFT 0.03
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available