R67C (p.Arg67Cys) variant of MAPK3 (P27361)
R67C (p.Arg67Cys) in MAPK3 (P27361) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
R67C (p.Arg67Cys) variant details
- p.Arg67Cys
- cosmic curated COSV53772
- 1000Genomes rs567762331
- ExAC rs567762331
- TOPMed rs567762331
- Missense
- Variant Prioritization Score for Impact Estimate 0.603
- REVEL 0.60
- CADD 28.80
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the 1KG:CDX population (allele frequency 0.0057)
- Structural context available