G54C (p.Gly54Cys) variant of MAPK3 (P27361)
G54C (p.Gly54Cys) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
G54C (p.Gly54Cys) variant details
- p.Gly54Cys
- rs1313150757
- NCI-TCGA Cosmic COSV9953
- cosmic curated COSV99531
- gnomAD rs1313150757
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.5
- REVEL 0.43
- CADD 28.10
- PolyPhen-2 0.98
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 7.3e-05)
- Structural context available