R15C (p.Arg15Cys) variant of MAPK3 (P27361)
R15C (p.Arg15Cys) in MAPK3 (P27361) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
R15C (p.Arg15Cys) variant details
- p.Arg15Cys
- rs766922585
- ClinGen CA8002982
- ClinVar RCV000893252
- 1000Genomes rs766922585
- Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.505
- REVEL 0.34
- CADD 22.60
- PolyPhen-2 0.00
- SIFT 0.05
- ClinVar: Likely benign (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available