S58L (p.Ser58Leu) variant of MAPK3 (P27361)
S58L (p.Ser58Leu) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
S58L (p.Ser58Leu) variant details
- p.Ser58Leu
- NCI-TCGA TCGA novel
- gnomAD rs1370684329
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.579
- REVEL 0.50
- AlphaMissense 0.68
- MetaLR 0.24
- MetaSVM -0.39
- CADD 32.00
- PolyPhen-2 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 5.4e-06)
- Structural context available