M55R (p.Met55Arg) variant of MAPK3 (P27361)
M55R (p.Met55Arg) in MAPK3 (P27361) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
M55R (p.Met55Arg) variant details
- p.Met55Arg
- gnomAD rs889768664
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.451
- REVEL 0.40
- CADD 25.60
- PolyPhen-2 0.02
- SIFT 0.03
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 0.00084)
- Structural context available