R64L (p.Arg64Leu) variant of MAPK3 (P27361)
R64L (p.Arg64Leu) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
R64L (p.Arg64Leu) variant details
- p.Arg64Leu
- NCI-TCGA Cosmic COSV9953
- cosmic curated COSV99531
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.279
- REVEL 0.08
- CADD 23.60
- PolyPhen-2 0.01
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.3e-05)
- Structural context available