E77K (p.Glu77Lys) variant of MAPK3 (P27361)
E77K (p.Glu77Lys) in MAPK3 (P27361) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
E77K (p.Glu77Lys) variant details
- p.Glu77Lys
- rs778826879
- NCI-TCGA Cosmic COSV5377
- cosmic curated COSV53772
- ExAC rs778826879
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.646
- REVEL 0.54
- CADD 29.20
- PolyPhen-2 0.92
- SIFT 0.00
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available