R96C (p.Arg96Cys) variant of MAPK3 (P27361)
R96C (p.Arg96Cys) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
R96C (p.Arg96Cys) variant details
- p.Arg96Cys
- NCI-TCGA Cosmic COSV9953
- cosmic curated COSV99531
- ExAC rs771940747
- TOPMed rs771940747
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.317
- REVEL 0.10
- CADD 24.50
- PolyPhen-2 0.02
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available