P22L (p.Pro22Leu) variant of MAPK3 (P27361)
P22L (p.Pro22Leu) in MAPK3 (P27361) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
P22L (p.Pro22Leu) variant details
- p.Pro22Leu
- ExAC rs770120964
- TOPMed rs770120964
- gnomAD rs770120964
- Missense
- Variant Prioritization Score for Impact Estimate 0.302
- REVEL 0.10
- CADD 22.60
- PolyPhen-2 0.00
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 1.9e-06)
- Structural context available