R87W (p.Arg87Trp) variant of MAPK3 (P27361)
R87W (p.Arg87Trp) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
R87W (p.Arg87Trp) variant details
- p.Arg87Trp
- rs750160678
- NCI-TCGA Cosmic COSV5377
- cosmic curated COSV53774
- ExAC rs750160678
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.601
- REVEL 0.74
- CADD 26.10
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available