E13D (p.Glu13Asp) variant of MAPK3 (P27361)
E13D (p.Glu13Asp) in MAPK3 (P27361) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
E13D (p.Glu13Asp) variant details
- p.Glu13Asp
- NCI-TCGA TCGA novel
- Ensembl rs1031507615
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- REVEL 0.17
- CADD 17.10
- PolyPhen-2 0.00
- SIFT 0.58
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.9e-05)
- Structural context available