FOS (Protein c-Fos) variants and mutations

FOS (also known as Protein c-Fos) is a human protein-coding gene encoding a protein c-Fos protein. Together with JUN-family proteins, it forms AP-1 transcriptional complexes that rapidly convert growth-factor and stress signals into gene-expression changes. Abnormal AP-1 activity can promote proliferation, inflammation, and tumor progression, and recurrent FOS rearrangements occur in certain bone tumors. This analysis covers 660 FOS variants and mutations. Of these, 83% have computational variant effect predictions. Disease context includes Crohn disease, inflammatory bowel disease, and smoking initiation. Example FOS variants include M2V, M2K, and S4*.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable FOS variants

Examples include M2V, M2K, S4*, S4L, S4S, G5D, G5S, G5V. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.