T69I (p.Thr69Ile) variant of FOS (Protein c-Fos)
T69I (p.Thr69Ile) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
T69I (p.Thr69Ile) variant details
- p.Thr69Ile
- TOPMed rs1472232276
- gnomAD rs1472232276
- Missense
- Variant Prioritization Score for Impact Estimate 0.491
- REVEL 0.31
- MetaLR 0.41
- MetaSVM -0.22
- CADD 26.90
- PolyPhen-2 0.94
- SIFT 0.02
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available