P43L (p.Pro43Leu) variant of FOS (Protein c-Fos)
P43L (p.Pro43Leu) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, published literature, and structural context.
P43L (p.Pro43Leu) variant details
- p.Pro43Leu
- gnomAD 14-75279110-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.459
- REVEL 0.31
- MetaLR 0.48
- MetaSVM -0.07
- CADD 27.30
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available