A12E (p.Ala12Glu) variant of FOS (Protein c-Fos)
A12E (p.Ala12Glu) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
A12E (p.Ala12Glu) variant details
- p.Ala12Glu
- ExAC rs749267828
- TOPMed rs749267828
- gnomAD rs749267828
- Missense
- Variant Prioritization Score for Impact Estimate 0.393
- REVEL 0.23
- MetaLR 0.40
- MetaSVM -0.25
- CADD 28.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available