A12G (p.Ala12Gly) variant of FOS (Protein c-Fos)
A12G (p.Ala12Gly) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
A12G (p.Ala12Gly) variant details
- p.Ala12Gly
- gnomAD 14-75279017-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.345
- REVEL 0.14
- MetaLR 0.40
- MetaSVM -0.27
- CADD 26.10
- PolyPhen-2 0.99
- SIFT 0.04
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available