P43S (p.Pro43Ser) variant of FOS (Protein c-Fos)
P43S (p.Pro43Ser) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
P43S (p.Pro43Ser) variant details
- p.Pro43Ser
- ExAC rs779749255
- TOPMed rs779749255
- gnomAD rs779749255
- Missense
- Variant Prioritization Score for Impact Estimate 0.457
- REVEL 0.26
- MetaLR 0.42
- MetaSVM -0.30
- CADD 23.90
- PolyPhen-2 1.00
- SIFT 0.07
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available