A86V (p.Ala86Val) variant of FOS (Protein c-Fos)
A86V (p.Ala86Val) in FOS (Protein c-Fos) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
A86V (p.Ala86Val) variant details
- p.Ala86Val
- rs1295646143
- NCI-TCGA Cosmic COSV1003
- cosmic curated COSV10033
- gnomAD rs1295646143
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.496
- REVEL 0.31
- MetaLR 0.45
- MetaSVM -0.12
- CADD 28.00
- PolyPhen-2 0.94
- SIFT 0.03
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available