N45S (p.Asn45Ser) variant of FOS (Protein c-Fos)
N45S (p.Asn45Ser) in FOS (Protein c-Fos) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
N45S (p.Asn45Ser) variant details
- p.Asn45Ser
- ExAC rs749214376
- gnomAD rs749214376
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.197
- REVEL 0.09
- MetaLR 0.05
- MetaSVM -1.04
- CADD 19.10
- PolyPhen-2 0.01
- SIFT 0.74
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available