P22L (p.Pro22Leu) variant of FOS (Protein c-Fos)
P22L (p.Pro22Leu) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
P22L (p.Pro22Leu) variant details
- p.Pro22Leu
- ExAC rs760763610
- TOPMed rs760763610
- gnomAD rs760763610
- Missense
- Variant Prioritization Score for Impact Estimate 0.566
- REVEL 0.50
- MetaLR 0.67
- MetaSVM 0.25
- CADD 29.30
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available